Following the merger of GlaxoWellcome and SmithKlineBeecham in 2001, the IT department within the UK commercial company GlaxoSmithKline (GSK) determined to adopt a radically new approach to IT. This approach focused the whole department on the generation of value and led to the adoption of new ideas and ways of working that have forged a close alignment with other business areas. This close working relationship has allowed the company to use IT as a truly strategic tool to become the only pharmaceutical company in the UK to adopt a different way of competing in the marketplace, and consequently to greatly increase sales. The speaker recounts the changes that were made in IT and how they emerged from a simple set of direction-setting ideas.